Philosophy of The Whole is a lie. Even when we look at some coherent whole, it is itself a part.
This is why Will to Power. There will never be a whole, our strive for coherence is not a path with ends but constant willing to power. We strive for and achieve part after part, and coherence between parts. This is the greatest pleasure, for us who have tasted it. The will to end, to whole, is the most bewildering thing to us, as the infinite multiplicity is more than any thing we were ever promised about wisdom, more wealth than whole seeking could ever conceive, and its beauty is that it is not better because it is more pleasurable, this it is, but because it is self-evidently true. Thus it is not even better, but simply true, and whole and end seeking becomes simply a wanton obstacleization, a bother, a cancer in the sense that it does not heed health, a true annoyance.
Let us diagnose, then. So far, I have seen no other treatment than what Nietzsche described, death. To help the end-seeker find end.