I'm going to try connecting Martin Luther and postmodernism/transhumanist nihilism.
I ran across the idea that philosophy (as the Greek projects of philosophy carried forward and being worked on in the Christian Middle Ages) and the Renaissance were aborted in their natural development by Luther, and that everything afterward is just a symptom of that problem. For example, the discrediting of Aristotle's conceptions of objectivity in truth and rationalist realism. So I want to explore this idea.
Luther achieves two things: he inserts a gap between the self ("soul", or subjectivity) and social capital, and he inserts a gap between the self as thought/ideation and the self as feeling/passion. The first gap he activates by denouncing the Catholic tradition of indulgences and by claiming that personal works or charity cannot lead to salvation; the second gap he activates by centering personal salvation on faith alone as a miracle of God's grace solely by our having faith, and by denouncing reason and free will as agents of sin or at least as merely secular concerns less important than faith.
I think these gaps are basically vacuums that nature filled in. The split between self and capital eventually led to Protestant work ethic and ultimately to capitalism (Max Weber), while the split between ideas and passions cut out reason/realism as a foundation for truthful thought and led to radical skepticism, subjectivism, relativism, and positivism.
Interestingly, while Luther wanted to eliminate greed and money as influences in so-called spiritual matters he actually freed greed and money to an even greater influence, because previously wealth was tied into the social substance as payments to the kings/princes "divine right of kings" concept as well as through being able to purchase salvation and the forgiveness of God through giving money to the church and other charitable deeds. In other words money was implicitly embedded in social structure and had a certain psychological link connecting it socially and to the forms of the past (politically and religiously). Luther did away with that, leading to a freedom of capital from such constraints, and while Luther thought this would lead to less greed it actually removed a barrier to greed, since after all human nature isn't going to suddenly change just because Luther removed these limits that he considered tied into greed/sin. Eventually Protestantism returned capital's place in the religious psyche through adopting as core virtues such things as industriousness, economic success and savings, frugality, hard work, etc.
But I think even more significant is how Luther divorced reason from faith, and I think this foreshadows Kant. Kant took this idea to the furthest extreme, made possible by Luther saying that reason should be free to exercise itself upon everything save for matters of God/faith. Reason became "mad" and was released without the natural connection to subjectivity, so that philosophy ultimately came to an aporia with logic, thought and reason on one side and feelings, sensation and passion on the other side. Kant simply took all that to its utmost conclusion. Yet from Kant we have come Hegel as a personification of Kant's aporiatic/schizoid method, as Hegel himself is basically "soulless" or at least is unable to reconcile his deeply penetrating reasoning with the subjectivity and self which reasons and which is ultimately targeted by reason. Hegel is a strange philosopher who dances around the aporia, trying to form rational links into the self but always failing to pass the threshold and actually conclude something of relevance to the self as substance and as living being. Hegel embodies the mad freedom of epistemology without recourse to ontology, or what is called phenomenology I suppose.
From Hegel then came both Schopenhauer and Marx. Schopenhauer continued the delusional methodology (denial of the notion of Aristotelian objective truth and the possibility of 'realism') and led to Nietzsche, who took it to a further extreme attempting to solve the problem of Kant and Socrates but without really absolving himself of their methods; Marx of course personifies the impersonal approach of Kant-->Hegel and culminates in recreating social economic theory without man as the center, indeed Marx basically makes politics and economics entirely inhuman (his core category and concept is the group, "class", and not the individual self or mind) [credit to Fixed Cross for his insight that Marxism removes human being from economics]. Thus the aporia pushed by Luther and philosophically enumerated by Kant became lived in Hegel (Kant lived it too) which led to Marx's psychosis and total break from reality in the abandonment of any recourse to truth. Marx doesn't even attempt to discover truth, for him there is no such thing as truth. Same basically goes for Nietzsche, but to a lesser degree than for Marx since Nietzsche's muse was Schopenhauer rather than Hegel, and Schopenhauer is already far more human than Hegel ever was.
From Marx and even too from Nietzsche to a degree comes pretty much everything wrong and insane with ("post")modern man: vacuous skepticism and solipsism, scientific nihilism, logical positivism and analytic philosophy, ironically both utilitarianism and new hedonism (following the same logically error that Luther made when he thought that he could decrease greed by removing barriers to it), critical theory and feminism, transhumanism (which includes transgenderism and transpersonalism); the Frankfurt school, New Left, Lacanian psychoanalysis, etc..